Sunday, August 9, 2015

James' Health: The Big Picture

I couldn't think of a creative title for this blog post, so hence the simplicity.  This entire post will be pretty nerdy/sciency so proceed with caution/interest level as far as reading goes. ;)

First, James has several genetic mutations that play a part in his current health status.  I won't go into explanation of them but for those of you medical types: he is compound heterozygous for MTHFR C677T and A1298C and hetero for all the other MTHFR genes; homozygous for both MAO A and B; hetero for COMT, homo for at least one of the BHMT and CBS; homo for 2 of the NOS; and has significant issues with both DAO and HNMT.

Now on to easier to understand things.  We primarily eat a "real food," often organic, local, low grain diet already.  However, he has Thiamine, Vitamin D3, Chromium, and Omega 3 deficiencies.  He's borderline deficient in B2, B12, Folate, Pantothene, Oleic, Calcium, and Vitamin C as well as having an elevated copper/low zinc ratio.

We know he has previously diagnosed Rheumatoid Arthritis and he's struggled with his cholesterol for years.  It was not exciting to hear that he does have an elevated amount of endothelial endovascular plaque present for his age.  His cholesterol was very high, and not in a good way.  His CRP (a marker of inflammation) is elevated, which is to be expected with the RA and cholesterol issues.  Unfortunately, his high cholesterol is mostly genetic and his lipid profile suggests he also has a hyper-absorption of dietary cholesterol.  Bye bye steaks...

His food testing is consistent with intestinal permeability and showed high sensitivities to egg white, gluten, beef, and milk/casein.   (And we're surprised that our kids have many of these same sensitivities?!)  As a result of these and the cholesterol results, James will be cutting all of these foods from his diet for a minimum of 6 months.  We've already been gluten-free since around November though he has had a few known exposures.  After that point, he will be allowed to try and add some of these foods back to his diet to see how he responds.  Gluten is gone for good and dairy may be as well based on the test scores.  He was also asked to add a significant amount of seafood to his diet both to replace the beef consumption and because of his Omega 3 deficiency.  It was recommended that he follow a mostly autoimmune and seafood based paleo protocol with some exceptions.

Fortunately he has no bacterial overgrowths, yeasts or parasites (yay!) but does have poor bacterial diversity in which we'll hit hard with particular probiotics and added fermented foods.

He also has borderline hypothyroid numbers.  His rT3 was elevated but still in an acceptable range so we'll try to treat with the above recommended diet/lifestyle changes first and proceed with medication if need be in the future.

Hormones were excellent.  Adrenals were in a normal range.  High levels of homocysteine (which come with many of the genetic issues above, so no surprise).  Fortunately, James is active and enjoys exercise so that's not something that he has to force.  Actually, he has another one of what I call his "crazy races" in just a few weeks called the BattleFrog. ;)

What's the overall big picture?  We're going to adjust his dietary intake for the next six months to see if it addresses many of these issues.  The inflammation from the food sensitivities could be further irritating his RA and cholesterol issues.  We're adding a specific multivitamin to cover the nutrient deficiencies and genetic defects that can be addressed.  We're also adding a probiotic rotation, Omega 3, and Vitamin D 3 regularly.  There were two other supplements recommended as needed for genetic stuff.  We're still waiting for results on any potential glucose issues but for now, this is where we stand!  Some of these issues will be retested in six months.  If we cannot get his cholesterol down, he will have to go on some type of medication.  Praying for grace in the healing process! Ultimately, we believe God is in control of it all.

Until next time...

Take care,

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